反应详情

Concentrated hydrochloric acid (0.5 mL) was added to a solution of (9-(4-(2-(tert-butyldimethylsilyloxy)ethyl)phenethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-methylthiazol-4-yl)methanone (example 5, step d) (0.3 g) in methanol (5 mL) and the resulting solution stirred for 1 h. The solvent was evaporated in vacuo and the residue azeotroped with toluene and redissolved in methanol (˜2 mL). The residue was diluted with methanol (10 mL) and applied to a SCX cartridge pre-wetted with methanol. The cartridge was washed with methanol (100 mL) and eluted with 1M ammonia in methanol solution (100 mL). The eluent was evaporated in vacuo to give the subtitled compound as a clear oil. Yield 0.2 g.

1. customThe solvent was evaporated in vacuo
2. customthe residue azeotroped with toluene
3. dissolutionredissolved in methanol (˜2 mL)
4. additionThe residue was diluted with methanol (10 mL)
5. washThe cartridge was washed with methanol (100 mL)
6. washeluted with 1M ammonia in methanol solution (100 mL)
7. customThe eluent was evaporated in vacuo