反应详情

The title compound was prepared as outlined in EXAMPLE 1 from 5-chloro-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid (Preparation 6) and 2-phenoxyethylamine. On completion of the reaction, the mixture was partitioned between water and dichloromethane on a hydrophobic frit, washing with dichloromethane. The organic filtrate was concentrated in vacuo then triturated with dichloromethane/methanol/ethyl acetate to give the title compound as a white solid. δH (d6 DMSO): 3.68 (2H, m), 4.13 (2H, m), 6.94 (3H, m), 7.25 (4H, m), 7.83 (1H, d), 8.95 (1H, t), 12.09 (1H, s). m/z (ES+)=316 [M+H]+; RT=3.45 min.

1. customThe title compound was prepared
2. customOn completion of the reaction
3. customthe mixture was partitioned between water and dichloromethane on a hydrophobic frit
4. washwashing with dichloromethane
5. concentrationThe organic filtrate was concentrated in vacuo
6. customthen triturated with dichloromethane/methanol/ethyl acetate