反应详情

温度

120 °C

2-Methyl-N-[1-(phenylsulfonyl)-6-(trimethylstannanyl)-1H-indazol-4-yl]-1,3-thiazole-4-carboxamide (50 mg) was placed in a microwave vial with Pd(PPh3)4 (10 mg) and 5-bromo-N,N-diethyl-3-pyridinesulfonamide (29 mg) was added. DMF (2 ml) was added and the reaction was heated under microwave irradiation for 15 min at 120° C. The reaction was evaporated to dryness and the residue was dissolved in IPA (2 ml) and 2M NaOH (aq) (1 ml). The reaction was stirred at RT for 3 h then evaporated to dryness. The residue was purified by MDAP (method E). The residue obtained was further purified on silica, eluting with 0-100% EtOAc/cyclohexane over 15 min followed by 0-20% MeOH/DCM, to give the title compound (13 mg).

1. additionwas added
2. customThe reaction was evaporated to dryness
3. dissolutionthe residue was dissolved in IPA (2 ml)
4. customthen evaporated to dryness
5. customThe residue was purified by MDAP (method E)
6. customThe residue obtained
7. customwas further purified on silica
8. washeluting with 0-100% EtOAc/cyclohexane over 15 min