反应详情

To a solution of 0.25 g 2-{3-methyl-5-[({[6-methyl-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}amino)sulfonyl]-2-thienyl}ethyl acetate in 5 ml methanol was added 0.01 ml 28% aqueous sodium hydroxide and the mixture was kept at room temperature for 3 h. The reaction mixture was partitioned between 10% citric acid and ethyl acetate. The phases were separated and the organic phase was washed with brine and evaporated. The residue was triturated with t-butylmethyl ether/heptane to yield 0.177 g of the title compound as off white powder MS (ISN) M−H+=422.4.

1. customThe reaction mixture was partitioned between 10% citric acid and ethyl acetate
2. customThe phases were separated
3. washthe organic phase was washed with brine
4. customevaporated
5. customThe residue was triturated with t-butylmethyl ether/heptane