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HRID1696994

反应详情

EQUATION

反应方程式

HRID 1696994 的结构方程式

REACTANTS

反应物

2
结构：COc1ccc(C(Nc2nc(Cl)nc3c2ncn3[C@@H]2C[C@H](N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)[C@@H](O)[C@H]2O)c2ccc(OC)cc2)cc1
HCID86622623

未命名化合物

结构：CCC(=O)N(C(=O)OC(C)(C)C)[C@@H]1C=C[C@H](n2cnc3c(NC(CC)CC)nc(Cl)nc32)C1
HCID86622634

未命名化合物

PRODUCTS

生成物

1
结构：CCC(=O)N(C(=O)OC(C)(C)C)[C@H]1C[C@@H](n2cnc3c(NC(CC)CC)nc(Cl)nc32)[C@H](O)[C@@H]1O
HCID86622635

未命名化合物

PROCEDURE

实验过程

The title compound is prepared from {(1S,4R)-4-[2-chloro-6-(1-ethyl-propylamino)-purin-9-yl]-cyclopent-2-enyl}-propionyl-carbamic acid tert-butyl ester using a procedure analogous to that of (1R,2S,3R,5S)-3-(6-{[bis-(4-methoxy-phenyl)-methyl]-amino}-2-chloro-purin-9-yl)-5-(di-Boc-amino)-cyclopentane-1,2-diol (see Example 1). Purification by reverse phase column chromatography (Isolute™ C18, 0-100% acetonitrile in water—0.1% TFA). 1H nmr (MeOD, 400 MHz); 8.10(s, 1H), 4.80(m, 1H), 4.65(m, 1H), 4.35(m, 1H), 4.20(m, 1H), 2.85(m, 2H), 2.60(m, 1H), 2.35(m, 1H), 1.70(m, 2H), 1.65(s, 9H), 1.60(m, 2H), 1.15(t, 3H), 0.95(t, 6H).

WORKUP

后处理

  1. customPurification by reverse phase column chromatography (Isolute™ C18, 0-100% acetonitrile in water—0.1% TFA)