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HRID1698331

反应详情

EQUATION

反应方程式

HRID 1698331 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)N[C@@H]1C[C@H](C(=O)O)CN(C(=O)OCC2c3ccccc3-c3ccccc32)C1
HCID57870323

未命名化合物

结构：CCNc1ccc2c(c1)N(CCCOC)C(=O)CO2
HCID59817731

6-(Ethylamino)-4-(3-methoxypropyl)-2H-1,4-benzoxazin-3(4H)-one

C14H20N2O3

PRODUCTS

生成物

1
结构：CCN(C(=O)[C@@H]1CNC[C@H](NC(=O)C(C)(C)C)C1)c1ccc2c(c1)N(CCCOC)C(=O)CO2
HCID15984738

未命名化合物

PROCEDURE

实验过程

The title compound is prepared analogously as described in Example 92A. using (3S*,5R*)-5-tert-butoxycarbonylamino-piperidine-1,3-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester and 6-ethylamino-4-(3-methoxy-propyl)-4H-benzo[1,4]oxazin-3-one. The product is purified by preparative HPLC (YMC Pack Pro C18, 10-100% CH3CN+0.1% TFA/H2O+0.1% TFA, 20 min, flow 20 ml/min); tR (HPLC, Nucleosil C18; 5-100% CH3CN+0.1% TFA/H2O+0.1% TFA for 8 min, flow 1.5 ml/min): 5.47 min.

WORKUP

后处理

  1. customThe product is purified by preparative HPLC (YMC Pack Pro C18, 10-100% CH3CN+0.1% TFA/H2O+0.1% TFA, 20 min, flow 20 ml/min)
  2. customtR (HPLC, Nucleosil C18; 5-100% CH3CN+0.1% TFA/H2O+0.1% TFA for 8 min, flow 1.5 ml/min)
  3. custom5.47 min.