反应详情

A mixture of methyl 5-tert-butyl-3-nitropyrrole-2-carboxylate (0.014 g, 0.062 mmol) and 10% Pd/C (3 mg) in dry MeOH (1 mL) was successively evacuated and purged with H2 three times, then shaken under an atmosphere of H2 (35 psi) for 1 h, diluted with CH2Cl2 and filtered through a pad of Celite®. The filtrate was concentrated under reduced pressure to give methyl 3-amino-5-tert-butylpyrrole-2-carboxylate as a bright yellow oil (0.012 g, 100%). 1H NMR (CDCl3) δ1.26 (s, 9H), 3.82 (s, 3H), 5.52 (d, J=2.8 Hz, 1H), 7.89 (br s, 2H). This material was used in the next step without further purification.

1. customwas successively evacuated
2. custompurged with H2 three times
3. additiondiluted with CH2Cl2
4. filtrationfiltered through a pad of Celite®
5. concentrationThe filtrate was concentrated under reduced pressure