反应详情

A mixture of 5-(2-chlorophenyl)-1-[2-(4-methylphenylsulfonyl)hydrazino]cyclohexen-3-one (2.0 g), 2-bromo-4′-chloroacetophenone (1.6 g), anhydrous potassium carbonate (1.8 g) and ethanol (50 ml) was refluxed for 13 hours. Under reduced pressure, the solvent was evaporated, and the residue was extracted with ethyl acetate. The organic layer was concentrated, and the residue was purified with silica gel column chromatography. The resulting crystals were recrystallized from ethyl acetate-hexane to give 7-(2-chlorophenyl)-4-(4-chlorophenyl)-5,6,7,8-tetrahydrocinnolin-5-one (0.2 g) as colorless crystals.

1. temperaturewas refluxed for 13 hours
2. customUnder reduced pressure, the solvent was evaporated
3. extractionthe residue was extracted with ethyl acetate
4. concentrationThe organic layer was concentrated
5. customthe residue was purified with silica gel column chromatography
6. customThe resulting crystals were recrystallized from ethyl acetate-hexane