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HRID1700985

反应详情

EQUATION

反应方程式

HRID 1700985 的结构方程式

REACTANTS

反应物

1
结构：CCC[C@H](C(=O)OC(C)(C)C)[C@@H](C/C=C/c1ccc(-c2ccccc2)c(C)c1)C(=O)N[C@H](C(=O)N[C@H](C)c1ccccc1)C(C)(C)C
HCID59875741

未命名化合物

PRODUCTS

生成物

1
结构：CCC[C@H](C(=O)OC(C)(C)C)[C@@H](CCCc1ccc(-c2ccccc2)c(C)c1)C(=O)N[C@H](C(=O)N[C@H](C)c1ccccc1)C(C)(C)C
HCID57077780

未命名化合物

收率 90,636.203%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

tert-Butyl (2S,3R,5E)-3-({[(1s)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-[3-methyl-(4-phenyl)phenyl]-2-(1-propyl)hex-5-enoate (437 gm, 0.68 mmol) in ethanol (50 mL) was hydrogenated over 10% palladium on charcoal (50 mg) at 3 bar and 20° C. for 17 h. The mixture was filtered through Arbocel filter aid and concentrated under reduced pressure. Flash chromatography (gradient elution with hexane:ethyl acetate) gave tert-butyl (2S,3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-[3-methyl-(4-phenyl)phenyl]-2-(1-propyl)hexanoate (395 gm, 62%), as a colourless foam.

WORKUP

后处理

  1. filtrationThe mixture was filtered through Arbocel
  2. filtrationfilter aid
  3. concentrationconcentrated under reduced pressure
  4. washFlash chromatography (gradient elution with hexane:ethyl acetate)