HRID1700997

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cccc(-c2ccc(/C=C/C[C@H](CC(=O)OC(C)(C)C)C(=O)N[C@H](C(=O)OCc3ccccc3)C(C)(C)C)cc2C)c1

HCID59875766

未命名化合物

PRODUCTS

生成物

结构：COc1cccc(-c2ccc(CCC[C@H](CC(=O)OC(C)(C)C)C(=O)N[C@H](C(=O)O)C(C)(C)C)cc2C)c1

HCID59875740

未命名化合物

收率 74,741.703%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

PROCEDURE

实验过程

According to the method of Preparation 19 c), tert-butyl (3R,5E)-3-({[(1S)-2,2-dimethyl-1-(benzyloxycarbonyl)propyl]amino}carbonyl)-6-(3′-methoxy-2-methylbiphen-4-yl]hex-5-enoate (1.040 g, 1.69 mmol) was hydrogenated over 10% palladium on charcoal to give tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-(carboxy)propyl]amino}carbonyl)-6-(3′-methoxy-2-methylbiphen-4-yl)hexanoate (664 g, 75%) as a colourless foam.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fdb9bfcf3b4f4afeb180eb2a68130878
来源数据集: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06350907B1
来源说明: uspto-grants-2002_02

反应 SMILES

[CH3:1][C:2]([CH3:45])([CH3:44])[C@H:3]([NH:14][C:15]([C@H:17]([CH2:26]/[CH:27]=[CH:28]/[C:29]1[CH:34]=[C:33]([CH3:35])[C:32]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([O:42][CH3:43])[CH:37]=2)=[CH:31][CH:30]=1)[CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[O:16])[C:4]([O:6]CC1C=CC=CC=1)=[O:5]>[Pd]>[CH3:1][C:2]([CH3:45])([CH3:44])[C@H:3]([NH:14][C:15]([C@H:17]([CH2:26][CH2:27][CH2:28][C:29]1[CH:34]=[C:33]([CH3:35])[C:32]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([O:42][CH3:43])[CH:37]=2)=[CH:31][CH:30]=1)[CH2:18][C:19]([O:21][C:22]([CH3:23])([CH3:24])[CH3:25])=[O:20])=[O:16])[C:4]([OH:6])=[O:5]