HRID1700998

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11768756

(S)-2-Methoxy-1-phenylethanamine

C9H13NO

结构：COc1cccc(-c2ccc(CCC[C@H](CC(=O)OC(C)(C)C)C(=O)N[C@H](C(=O)O)C(C)(C)C)cc2C)c1

HCID59875740

未命名化合物

PRODUCTS

生成物

结构：COC[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCc1ccc(-c2cccc(OC)c2)c(C)c1)CC(=O)OC(C)(C)C)C(C)(C)C)c1ccccc1

HCID59106438

未命名化合物

收率 81%

PROCEDURE

实验过程

According to the procedure of Preparation 19 d), tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-(carboxy)propyl]amino}carbonyl)-6-(3′-methoxy-2-methylbiphen-4-yl)hexanoate (660 mg, 1.26 mmol) was reacted with (1S)-2-methoxy-1-phenylethylamine (190 mg, 1.260 mmol). Work-up as above, followed by flash chromatography (eluting with hexane:ethyl acetate=3:1) to give tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1s)-2-methoxy-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-(3′-methoxy-2-methylbiphen-4-yl)hexanoate (672 mg, 81%) as a colourless foam.

WORKUP

后处理

washfollowed by flash chromatography (eluting with hexane:ethyl acetate=3:1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a81533a413ac4a3c9a02f330f3db9f05
来源数据集: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06350907B1
来源说明: uspto-grants-2002_02

反应 SMILES

[CH3:1][C:2]([CH3:38])([CH3:37])[C@H:3]([NH:7][C:8]([C@H:10]([CH2:19][CH2:20][CH2:21][C:22]1[CH:27]=[C:26]([CH3:28])[C:25]([C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([O:35][CH3:36])[CH:30]=2)=[CH:24][CH:23]=1)[CH2:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])=[O:9])[C:4]([OH:6])=O.[CH3:39][O:40][CH2:41][C@@H:42]([NH2:49])[C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1>>[CH3:1][C:2]([CH3:38])([CH3:37])[C@H:3]([NH:7][C:8]([C@H:10]([CH2:19][CH2:20][CH2:21][C:22]1[CH:27]=[C:26]([CH3:28])[C:25]([C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([O:35][CH3:36])[CH:30]=2)=[CH:24][CH:23]=1)[CH2:11][C:12]([O:14][C:15]([CH3:16])([CH3:18])[CH3:17])=[O:13])=[O:9])[C:4]([NH:49][C@@H:42]([C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1)[CH2:41][O:40][CH3:39])=[O:6]