HRID1701057

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：CC(C)(C)[Si](C)(C)OCC(C=O)Cc1ccc2ccccc2c1

HCID18318362

未命名化合物

HCID21897273

未命名化合物

反应SMILES：CC(C)(C)OC(=O)N[C@H](Cc1ccc2ccccc2c1)CS(=O)(=O)c1ccccc1

HCID54424850

未命名化合物

PRODUCTS

产物

反应SMILES：CC(C)(C)OC(=O)N[C@@H](C=CC(CO[Si](C)(C)C(C)(C)C)Cc1ccc2ccccc2c1)Cc1ccc2ccccc2c1

HCID54070080

未命名化合物

PROCEDURE

实验过程

This compound was prepared as in example 9. ((1R)-1-benzenesulfonylmethyl-2-(2-naphthyl)ethyl)carbamic acid tert-butylester (3.71 g; 8.74 mmol) and 2-(tert-butyldimethylsilanyloxymethyl)-3-(2-naphthyl)propionaldehyde (4.3 g; 13.11 mmol) were used as starting materials. Chromatography was carried out using diethylether/heptane 1:3 as eluent on silica (5×25 cm) to afford 2.20 g of ((1R)-4-(tert-butyldimethylsilanyloxymethyl)-1-((2-naphthyl)methyl)-5-(2-naphthyl)pent-2-enyl)carbamic acid tert-butyl ester as a mixture of isomers.

WORKUP

后处理

customThis compound was prepared as in example 9

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-a68b5ed1f6d243b3a73883ea82b789a7
来源数据集: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US06350767B1
来源说明: uspto-grants-2002_02

反应SMILES

[C:1]([O:5][C:6](=[O:30])[NH:7][C@@H:8](CS(C1C=CC=CC=1)(=O)=O)[CH2:9][C:10]1[CH:19]=[CH:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=1)([CH3:4])([CH3:3])[CH3:2].[Si:31]([O:38][CH2:39][CH:40]([CH2:43][C:44]1[CH:53]=[CH:52][C:51]2[C:46](=[CH:47][CH:48]=[CH:49][CH:50]=2)[CH:45]=1)C=O)([C:34]([CH3:37])([CH3:36])[CH3:35])([CH3:33])[CH3:32].[CH2:54](OCC)[CH3:55].CCCCCCC>>[C:1]([O:5][C:6](=[O:30])[NH:7][C@H:8]([CH2:9][C:10]1[CH:19]=[CH:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=1)[CH:54]=[CH:55][CH:40]([CH2:39][O:38][Si:31]([C:34]([CH3:36])([CH3:35])[CH3:37])([CH3:33])[CH3:32])[CH2:43][C:44]1[CH:45]=[CH:46][C:47]2[C:52](=[CH:51][CH:50]=[CH:49][CH:48]=2)[CH:53]=1)([CH3:3])([CH3:4])[CH3:2]