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HRID1702206

反应详情

EQUATION

反应方程式

HRID 1702206 的结构方程式

REACTANTS

反应物

3
结构：C[C@@H](CSC(=O)c1ccccc1)C(=O)Cl
HCID12878434

未命名化合物

结构：CCN1C[C@@H](C(=O)OC(C)(C)C)NC1=O
HCID13053981

4-Imidazolidinecarboxylic acid, 1-ethyl-2-oxo-, 1,1-dimethylethyl ester, (S)-

C10H18N2O3

结构：CC(C)(C)[O-].[K+]
HCID23665647

2-Methyl-2-propanol, potassium salt

C4H9KO

PRODUCTS

生成物

1
结构：CCN1C[C@@H](C(=O)OC(C)(C)C)N(C(=O)[C@H](C)CSC(=O)c2ccccc2)C1=O
HCID13054001

未命名化合物

收率 75.8%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

3.0 g of tert.-butyl (4S)-1-ethyl-2-oxo-imidazolidine-4-carboxylate, 1.6 g of potassium tert.-butoxide, (2S)-3-benzoylthio-2-methylpropionyl chloride (prepared from 3.2 g of (2S)-3-benzoylthio-2-methylpropionic acid and 10 ml of thionyl chloride) and 40 ml of tetrahydrofuran are treated in the same manner as described in Example 2-(2). Then, the oily residue obtained is purified by silica gel chromatography (Solvent, toluene-ethyl acetate(20:1)). 4.2 g of tert.-butyl (4S)-1-ethyl-3-[(2S)-3-benzoylthio-2-methylpropionyl]-2-oxo-imidazolidine-4-carboxylate are obtained as colorless crystals.

WORKUP

后处理

  1. customThen, the oily residue obtained
  2. customis purified by silica gel chromatography (Solvent, toluene-ethyl acetate(20:1))