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HRID1702214

反应详情

EQUATION

反应方程式

HRID 1702214 的结构方程式

REACTANTS

反应物

3
结构：C[C@@H](CSC(=O)c1ccccc1)C(=O)Cl
HCID12878434

未命名化合物

结构：CC(C)(C)OC(=O)[C@@H]1CN(Cc2ccccc2)C(=O)N1
HCID13053983

未命名化合物

结构：CC(C)(C)[O-].[K+]
HCID23665647

2-Methyl-2-propanol, potassium salt

C4H9KO

PRODUCTS

生成物

1
结构：C[C@H](CSC(=O)c1ccccc1)C(=O)N1C(=O)N(Cc2ccccc2)C[C@H]1C(=O)OC(C)(C)C
HCID13193172

未命名化合物

收率 76.6%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

27.6 g of tert.-butyl (4S)-1-benzyl-2-oxo-imidazolidine-4-carboxylate, 11.2 g of potassium tert.-butoxide, (2S)-3-benzoylthio-2-methylpropionyl chloride (prepared from 22.4 g of (2S)-3-benzoylthio-2-methylpropionic acid and 25 ml of thionyl chloride) and 200 ml of tetrahydrofuran are treated in the same manner as described in Example 2-(2). Then, the oily residue obtained is purified by silica gel chromatography (Solvent, toluene-ethyl acetate(20:1)) and triturated with n-hexane. 34.1 g of tert.-butyl (4S)-1-benzyl-3-[(2S)-3-benzoylthio-2-methylpropionyl]-2-oxo-imidazolidine-4-carboxylate are obtained as colorless crystals. Yield: 70.7%

WORKUP

后处理

  1. customThen, the oily residue obtained
  2. customis purified by silica gel chromatography (Solvent, toluene-ethyl acetate(20:1))
  3. customtriturated with n-hexane