反应详情

850 g (3 moles) 2-(2-thienyl)-ethyl paratoluene sulfonate and 850 g (6 moles) ortho-chlorobenzylamine are dissolved in 5.2 liters acetonitrile and the mixture is refluxed during 6.5 hours. After filtration, 630 g ortho-chlorobenzylamine paratoluene sulfonate are removed by filtration. The filtrate is concentrated and the residue is taken up into diisopropyl ether and 500 ml 2N sodium hydroxide. The organic phase is separated and is made acidic with 3N hydrochloric acid. The resulting hydrochloride precipitates out; it is collected by filtration, suction filtered and washed with acetone, to give 684 g (Yield: 78%) N-(2-chloro-benzyl)-2-(2-thienyl)-ethylamine hydrochloride.

1. temperaturethe mixture is refluxed during 6.5 hours
2. filtrationAfter filtration, 630 g ortho-chlorobenzylamine paratoluene sulfonate
3. customare removed by filtration
4. concentrationThe filtrate is concentrated
5. customThe organic phase is separated
6. customThe resulting hydrochloride precipitates out
7. filtrationit is collected by filtration, suction
8. filtrationfiltered
9. washwashed with acetone