HRID1706837

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID702

Ethanol

C2H6O

HCID20334452

未命名化合物

$结构：CC(=O)OCC1=C(C(=O)[O-])N2C(=O)[C@@H](NC(=O)/C(=N\O)c3ccco3)[C@H]2SC1.[Na+]$

HCID23694123

未命名化合物

PRODUCTS

生成物

$结构：CNC(=O)N(C)C(=O)CC(C)O/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(COC(C)=O)CS[C@H]12)c1ccco1$

HCID22811331

未命名化合物

收率 73%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

This compound was prepared from 1-(2-bromo-2-methylpropionyl)-1,3-dimethylurea and (6R,7R)-3-acetoxymethyl-7-[Z-2-(fur-2-yl)-2-hydroxyiminoacetamido]-ceph-3-em-4-carboxylic acid sodium salt by the method described in Example 1. Yield 73%, λmax (EtOH) 274 nm (ε12,500), νmax (Nujol) 3300 (NH), 3700-2100 (bonded OH), 1789 (β-lactam), 1730 (CO2H), 1685, 1535 (CONH), τ(DMSO d6) 0.18 (CONH), 2.11, 3.28, 3.31 (furyl), 4.11, (7H), 4.77 (6H), 4.97, 6.29 (3--CH2), 6.29, 6.49 (2--CH2), 6.75 (NMe), 7.28 (NHMe), 7.93 (OAc), 8.41 (CMe2).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e160bc9974e04e67889cda7b01838b89
来源数据集: uspto-grants-1980_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04208517
来源说明: uspto-grants-1980_06

反应 SMILES

Br[C:2]([CH3:12])(C)[C:3]([N:5]([CH3:10])[C:6]([NH:8][CH3:9])=[O:7])=[O:4].[Na+].[C:14]([O:17][CH2:18][C:19]1[CH2:20][S:21][C@@H:22]2[C@H:29]([NH:30][C:31](=[O:40])/[C:32](/[C:35]3[O:36][CH:37]=[CH:38][CH:39]=3)=[N:33]\[OH:34])[C:28](=[O:41])[N:23]2[C:24]=1[C:25]([O-:27])=[O:26])(=[O:16])[CH3:15].[CH3:42]CO>CS(C)=O>[C:14]([O:17][CH2:18][C:19]1[CH2:20][S:21][C@@H:22]2[C@H:29]([NH:30][C:31](=[O:40])/[C:32](=[N:33]\[O:34][CH:12]([CH2:2][C:3]([N:5]([CH3:10])[C:6]([NH:8][CH3:9])=[O:7])=[O:4])[CH3:42])/[C:35]3[O:36][CH:37]=[CH:38][CH:39]=3)[C:28](=[O:41])[N:23]2[C:24]=1[C:25]([OH:27])=[O:26])(=[O:16])[CH3:15]