反应详情

Formula (XII): R1 =n-propyl, R2 =methyl, X=N, Y=C--SO2N(CH3)2X Y=double bond, ##STR122## 8 g of {7-n-propyl-5-methyl-8-[(2'-cyano-4-biphenylyl)methyl]-1,2,4-triazolo[1,5-c]pyrimidin-2-yl}sulphonyl chloride, prepared in Example 45, are stirred with 40 ml of a 40% aqueous solution of dimethylamine for one hour at 50° C. The mixture is then extracted with chloroform, and the organic phase is dried over magnesium sulphate and then concentrated under vacuum to give 5.5 g of N,N-dimethyl-{7-n-propyl-5-methyl-8-[(2'-cyano-4-biphenylyl)methyl]-1,2,4-triazolo[1,5-c]pyrimidin-2-yl}sulphonamide in the form of crystals of melting point 158° C. The following examples were prepared according to the same procedure:

1. extractionThe mixture is then extracted with chloroform
2. dry with materialthe organic phase is dried over magnesium sulphate
3. concentrationconcentrated under vacuum