Ammonia → 3-Cyclohexyl-2-[4-(pyrid-2-yl-methoxy)phenyl]propionic acid N-hydroxy-N-methyl-amide
Reaction equation
[CH:1]1([CH2:7][CH:8]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=3)=[CH:14][CH:13]=2)[C:9](O)=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C1C2C(=CC=CC=2)C=CC=1COC1C=C(C([O:54][N:55]=[CH:56]C(O)=O)CCCC2C=CC=CC=2)C=CC=1.N>>[OH:54][N:55]([CH3:56])[C:9](=[O:10])[CH:8]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=2)=[CH:14][CH:13]=1)[CH2:7][CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1Participants
4
Procedure
The desired material was prepared according to the procedures described in Example 5 substituting 3-cyclohexyl-2-[4-(pyrid-2-yl-methoxy)phenyl]propionic acid for {[1-(3-[2-naphthylmethoxyl]phenyl)-4-phenylbutyl]oximino}acetic acid. 1H NMR (DMSO-d6, 300 MHz) δ 0.85 (m, 2H), 1.1 (m, 4H), 1.43 (m, 1H), 1.6 (m, 5H), 1.8 (m, 1H), 3.04 (s, 3H), 4.25 (m, 1H), 5.24 (s, 2H), 6.93 (d, J=7Hz, 2H), 7.2 (d, J=7Hz, 2H), 7.33 (m, 1H), 7.5 (d, J=7Hz, 1H), 7.82 (dt, J=7Hz, 2Hz, 1H), 8.58 (m, 1H), 9.8 (bs, 1H). IR (CDCl3): 3620, 3440, 1610 with shoulder 1660 cm-1. MS (DCI/NH3) m/e 369 (M+H)+.
Sources & evidence
- ORD record
- ord-13784590faa9405bac407d4833a02307
- Source dataset
- uspto-grants-1994_10
- Patent number
- US05358955
Reaction notes
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