HRID1708891

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(COC(=O)CC(C)=O)CS[C@H]12)c1nsc(NC(=O)OC(C)(C)C)n1$

HCID88417345

未命名化合物

PRODUCTS

生成物

$结构：CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(COC(=O)CC(C)=O)CS[C@H]12)c1nsc(N)n1$

HCID88417261

未命名化合物

收率 92.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6422

未命名化合物

PROCEDURE

实验过程

To 50 ml of trifluoroacetic acid is added 13 g of 7β-[2-(5-tert-butoxycarbonylamino-1,2,4-thiadiazol-3-yl)-2(Z)-methoxyiminoacetamido]-3-(3-oxobutyryloxymethyl)-3-cephem-4-carboxylic acid with stirring under ice-cooling. The cooling bath is removed and stirring is continued for 30 minutes. Trifluoroacetic acid is evaporated off under reduced pressure. To the residue is added 100 ml of ethyl acetate and the ethyl acetate is removed under reduced pressure. To the residue is added 100 ml of diethyl ether. Trituration and filtration of the resulting powder give 10 g of the above-identified compound.

WORKUP

后处理

temperaturecooling
customThe cooling bath is removed
stirringstirring
customTrifluoroacetic acid is evaporated off under reduced pressure
additionTo the residue is added 100 ml of ethyl acetate
customthe ethyl acetate is removed under reduced pressure
additionTo the residue is added 100 ml of diethyl ether
filtrationTrituration and filtration of the resulting powder