HRID1710369

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID222

Ammonia gas

H3N

结构：NC1=NC(CCc2nc3cc(-c4ccccc4)cnc3[nH]2)CCCC1

HCID178508386

未命名化合物

2 次

结构：O=S(=O)(c1ccc(-c2cnc3[nH]c(CCC4CCCCC(=S)N4)nc3c2)cc1)N1CCC1

HCID178527293

未命名化合物

2 次

PRODUCTS

生成物

结构：NC1=NC(CCc2nc3cc(-c4ccc(S(=O)(=O)N5CCC5)cc4)cnc3[nH]2)CCCC1

HCID178508387

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

The title compound is synthesized as described for 7-[2-(6-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)-ethyl]-4,5,6,7-tetrahydro-3H-azepin-2-ylamine (compound 1) from 92 mg of 7-(2-{6-[4-(azetidine-1-sulfonyl)-phenyl]-3H-imidazo[4,5-b]pyridin-2-yl}-ethyl)-azepane-2-thione (compound A6) and 4.50 ml of methanol containing ammonia (strength: 7.0 M) at 50° C. for 70 hours. Purification by flash chromatography on LiChroprep-NH2® (eluent gradient: dichloromethane/0-100 vol. % methanol) affords 56 mg of the title compound as an amorphous solid of m.p. 154° C. (decomp.). ESI-MS: 453.2 (MH+). TLC: Rf=0.23 (LiChroprep-NH2® HPTLC, neat methanol).

WORKUP

后处理

customThe title compound is synthesized
customPurification by flash chromatography on LiChroprep-NH2® (eluent gradient: dichloromethane/0-100 vol. % methanol)