反应详情

The title compound is synthesized as described for 7-[2-(6-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)-ethyl]-4,5,6,7-tetrahydro-3H-azepin-2-ylamine (compound 1) from 157 mg of 7-(2-{6-[4-(4-ethyl-piperazine-1-sulfonyl)-phenyl]-3H-imidazo[4,5-b]pyridin-2-yl}-ethyl)-azepane-2-thione (compound A7) and 6.90 ml of methanol containing ammonia (strength: 7.0 M) at 50° C. for 90 hours. Purification by flash chromatography on LiChroprep-NH2® (eluent gradient: ethyl acetate/0-100 vol. % 2-propanol) affords 28 mg of the title compound as an amorphous solid of m.p. 199° C. ESI-MS: 528.2 (MNH4+), 510.4 (MH+), TLC: Rf=0.30 (LiChroprep-NH2® HPTLC, neat methanol).

1. customThe title compound is synthesized
2. customPurification by flash chromatography on LiChroprep-NH2® (eluent gradient: ethyl acetate/0-100 vol. % 2-propanol)