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HRID1710652

反应详情

EQUATION

反应方程式

HRID 1710652 的结构方程式

REACTANTS

反应物

3
结构：Cc1ccc(S(=O)(=O)O)cc1
HCID6101

4-Methylbenzenesulfonic acid

C7H8O3S

结构：COC(OC)OC
HCID9005

Trimethoxymethane

C4H10O3

结构：COc1cc(N2CCN(C(=O)Cn3c(=O)oc4cc(C(=N)NO)ccc43)CC2)ccc1Cl
HCID178493023

3-[2-[4-(4-chloro-3-methoxyphenyl)piperazin-1-yl]-2-oxoethyl]-N'-hydroxy-2-oxo-1,3-benzoxazole-6-carboximidamide

C21H22ClN5O5

PRODUCTS

生成物

1
结构：COc1cc(N2CCN(C(=O)Cn3c(=O)oc4cc(-c5ncon5)ccc43)CC2)ccc1Cl
HCID16059630

未命名化合物

PROCEDURE

实验过程

A mixture 3-{2-[4-(4-chloro-3-methoxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-N-hydroxy-2-oxo-2,3-dihydro-benzooxazole-6-carboxamidine (65 mg), trimethyl orthoformate (3 ml) and p-toluenesulfonic acid (PTSA) (23 mg) was stirred at 103° C. overnight. The resultant solution was evaporated to dryness and then purified by flash chromatography to provide 3-{2-[4-(4-chloro-3-methoxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-6-[1,2,4]oxadiazol-3-yl-3H-benzooxazol-2-one (51): LCMS observed for (M+H)+: 470.5.

WORKUP

后处理

  1. customThe resultant solution was evaporated to dryness
  2. custompurified by flash chromatography