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HRID1710977

反应详情

EQUATION

反应方程式

HRID 1710977 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)NC1CCN(C(=O)c2cc3ncnc(Oc4ccc(NC(=S)NC(=O)Cc5ccccc5)cc4F)c3s2)C1
HCID59424627

未命名化合物

结构：Cl.Cl.O=C(Cc1ccccc1)NC(=S)Nc1ccc(Oc2ccnc3cc(-c4ccc(N5CCNCC5)cc4)sc23)c(F)c1
HCID86604176

未命名化合物

PRODUCTS

生成物

1
结构：Cl.NC1CCN(C(=O)c2cc3ncnc(Oc4ccc(NC(=S)NC(=O)Cc5ccccc5)cc4F)c3s2)C1
HCID87545777

未命名化合物

收率 40%

PROCEDURE

实验过程

Following the procedure described above for the synthesis of compound 159 (scheme 30, example 121) but substituting Boc-protected amino compound 158 for the Boc-protected amino compound 26l, title compound 191 was obtained in 40% yield. 1H NMR (400 MHz, DMSO-d6) δ (ppm): 8.77 (s, 1H), 8.12 (s, 0.5H), 8.06 (s, 0.5H), 7.92(dd, J=2.4 and 12.0 Hz, 1H), 7.54(t, J=8.4 Hz, 1H), 7.48(dd, J=2.4 and 8.4 Hz, 1H), 7.36-7.31 (m, 4H), 7.30-7.25 (m, 1H), 4.2-3.80 (m, 1H), 3.08 (s, 2H), 3.80-3.50 (m, 4H), 2.10-1.98 (m, 1H), 1.82-1.64(m, 1H). LRMS (M+1) 550.6 (100%).