反应详情

温度

50 °C

To a solution of 0.15 mmol (4-hydroxy-piperidin-1-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone (Example 3(a)) in 3 ml tetrahydrofuran were added successively 0.18 mmol 4-nitrophenol, 0.18 mmol triphenylphosphine and 0.18 mmol di-tert-butyl azodicarboxylate. The reaction mixture was stirred at 50° C. for 16 h and was then cooled to room temperature and concentrated in vacuo. The crude material was purified by reversed phase HPLC (acetonitrile/water) to afford the title compound as a white crystalline solid (yield 27%). MS (m/e): 463.4 (M+H+, 100%).

1. temperaturewas then cooled to room temperature
2. concentrationconcentrated in vacuo
3. customThe crude material was purified by reversed phase HPLC (acetonitrile/water)