HRID1712261

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID118927

1-Chloro-3-methoxypropane

C4H9ClO

结构：COc1ccccc1COCCCOc1ccc(C2CCN(C(=O)OCc3ccccc3)CC2OCc2cccc3[nH]ccc23)cc1

HCID68499385

未命名化合物

PRODUCTS

生成物

结构：COCCCn1ccc2c(COC3CN(C(=O)OCc4ccccc4)CCC3c3ccc(OCCCOCc4ccccc4OC)cc3)cccc21

HCID68502492

未命名化合物

PROCEDURE

实验过程

Analogously to Example 10a, 0.148 g of benzyl 3-(1H-indol-4-ylmethoxy)-4-{4-[3-(2-methoxy-benzyloxy)propoxy]phenyl}piperidine-1-carboxylate (Example 10b2) and 0.110 ml of 1-chloro-3-methoxypropane are reacted. The title compound is obtained as a slightly yellowish oil. Rf=0.25 (1:1 EtOAc-heptane); Rt=27.24 min (II).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8a5fdfa04af24477a48844a42f8cb888
来源数据集: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07790715B2
来源说明: uspto-grants-2010_09

反应 SMILES

[NH:1]1[C:9]2[C:4](=[C:5]([CH2:10][O:11][CH:12]3[CH:17]([C:18]4[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][CH2:27][O:28][CH2:29][C:30]5[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=5[O:36][CH3:37])=[CH:20][CH:19]=4)[CH2:16][CH2:15][N:14]([C:38]([O:40][CH2:41][C:42]4[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=4)=[O:39])[CH2:13]3)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.Cl[CH2:49][CH2:50][CH2:51][O:52][CH3:53]>>[CH3:37][O:36][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=1[CH2:29][O:28][CH2:27][CH2:26][CH2:25][O:24][C:21]1[CH:20]=[CH:19][C:18]([CH:17]2[CH2:16][CH2:15][N:14]([C:38]([O:40][CH2:41][C:42]3[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=3)=[O:39])[CH2:13][CH:12]2[O:11][CH2:10][C:5]2[CH:6]=[CH:7][CH:8]=[C:9]3[C:4]=2[CH:3]=[CH:2][N:1]3[CH2:49][CH2:50][CH2:51][O:52][CH3:53])=[CH:23][CH:22]=1