HRID1712493

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID46835223

6-(Chloromethyl)-4-(3-methoxypropyl)-2H-1,4-benzoxazin-3(4H)-one

C13H16ClNO3

结构：C=CCOc1ccc(C2CCN(C(=O)OCc3ccccc3)CC2O)cc1

HCID68501269

未命名化合物

PRODUCTS

生成物

结构：C=CCOc1ccc(C2CCN(C(=O)OCc3ccccc3)CC2OCc2ccc3c(c2)N(CCCOC)C(=O)CO3)cc1

HCID68505876

未命名化合物

PROCEDURE

实验过程

Analogously to Method D, 20.0 g of benzyl 4-(4-allyloxyphenyl)-3-hydroxypiperidine-1-carboxylate and 15.6 g of 6-chloromethyl-4-(3-methoxypropyl)-4H-benzo[1,4]oxazin-3-one (Example 2a) are reacted. The title compound is obtained as a yellowish oil. Rf=0.20 (1:1 EtOAc-heptane); Rt=5.43.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-89411f9b58bc40be96c50d5ca0f84e36
来源数据集: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07790715B2
来源说明: uspto-grants-2010_09

反应 SMILES

[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]2[CH2:16][CH2:15][N:14]([C:17]([O:19][CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[O:18])[CH2:13][CH:12]2[OH:27])=[CH:7][CH:6]=1)[CH:2]=[CH2:3].Cl[CH2:29][C:30]1[CH:31]=[CH:32][C:33]2[O:38][CH2:37][C:36](=[O:39])[N:35]([CH2:40][CH2:41][CH2:42][O:43][CH3:44])[C:34]=2[CH:45]=1>>[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]2[CH2:16][CH2:15][N:14]([C:17]([O:19][CH2:20][C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)=[O:18])[CH2:13][CH:12]2[O:27][CH2:29][C:30]2[CH:31]=[CH:32][C:33]3[O:38][CH2:37][C:36](=[O:39])[N:35]([CH2:40][CH2:41][CH2:42][O:43][CH3:44])[C:34]=3[CH:45]=2)=[CH:7][CH:6]=1)[CH:2]=[CH2:3]