反应详情

温度

60 °C

8-[3′-(3-Aminopropoxy)biphenyl-4-ylmethylamino]-adenosine (0.2 g) was suspended in tetrahydrofuran (2 mL), N-benzyloxycarbonyl-1H-pyrazole-1-carboxamidine (0.47 g) was added, and the resulting mixture was stirred at 60° C. for 24 hours. The reaction mixture was concentrated under reduced pressure and the residue obtained was purified by column chromatography on aminopropylated silica gel (eluent: ethyl acetate/methanol=8/1-6/1). A mixture of the compound obtained and 10% palladium on carbon (43.8 wt % H2O, 0.05 g) in methanol (2 mL) was stirred at room temperature for 4 hours under a hydrogen atmosphere. The insoluble material was filtered out and the filtrate was concentrated under reduced pressure to give the title compound (0.05 g).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customthe residue obtained
3. customwas purified by column chromatography on aminopropylated silica gel (eluent: ethyl acetate/methanol=8/1-6/1)
4. additionA mixture of the compound
5. customobtained
6. filtrationThe insoluble material was filtered out
7. concentrationthe filtrate was concentrated under reduced pressure