4-(2-Bromo-4-nitrophenyl)morpholine → 3-Bromo-4-morpholinoaniline

HRID 1713815Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1713815
C(N1CCN(C2C=CC(N)=CC=2C)CC1)(=O)C.[Br:18][C:19]1[CH:24]=[C:23]([N+:25]([O-])=O)[CH:22]=[CH:21][C:20]=1[N:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>>[Br:18][C:19]1[CH:24]=[C:23]([NH2:25])[CH:22]=[CH:21][C:20]=1[N:28]1[CH2:29][CH2:30][O:31][CH2:32][CH2:33]1

Komponenten

3

Edukt 2

HCID 27658874-(2-Bromo-4-nitrophenyl)morpholineHCID 5311936[4-(4-Acetylpiperazin-1-yl)-3-methylphenyl]amine

Produkt 1

HCID 6750723-Bromo-4-morpholinoaniline

Versuchsvorschrift

Following the general procedure of Intermediate 36 but using 4-(2-bromo-4-nitrophenyl)morpholine as starting material and allowing 5 h for hydrogenation and subsequently purifying by chromatography eluting with EtOAc/isohexane there was thus obtained the title compound (Intermediate 75) in 24% yield; 1H NMR δ 6.90 (1H, d), 6.80 (1H, s), 6.50 (1H, dd), 5.00 (2H, s), 5.40 (1H, d), 3.70-3.60 (4H, m), 2.80-2.70 (4H, m); MS m/e MH+ 258.

Aufarbeitung

  1. customsubsequently purifying by chromatography
  2. washeluting with EtOAc/isohexane there

Quellen und Nachweise

ORD-Eintrag
ord-f12c3493c41640339bc33624ee87273f
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07795283B2

Notizen zur Reaktion

Wird geladen…