反应详情

A sol. of [3-(4-bromo-phenyl)-propoxy]-tert-butyl-dimethyl-silane (102.1 g, 310 mmol) in THF (1.50 L) under nitrogen is cooled to −78° C. BuLi (1.5M in hexane, 212 mL, 318 mmol) is added. After 30 min, ZnCl2 (1M in THF, 465 mL, 465 mmol) is added. The mixture is allowed to warm up to rt. (rac.)-(1R*,5S*)-9-Methyl-7-trifluoromethanesulfonyloxy-3,9-diaza-bicyclo[3.3.1]non-6-ene-3,6-dicarboxylic acid 3-tert-butyl ester 6-ethyl ester (83.6 g, 155 mmol) in THF (100 mL) and then Pd(PPh3)4 (4.48 g, 3.87 mmol) are added. The mixture is heated to reflux for 30 min, and allowed to cool to rt. The mixture is diluted with EtOAc and washed with aq. 1M NaOH (1×). The org. extracts are dried over MgSO4, filtered, and the solvents are removed under reduced pressure. Purification of the residue by FC (MeOH/CH2Cl2 1:49→1:24→3:47→2:23) yields the title compound (88.6 g, virtually quantitative). LC-MS: tR=0.98 min; ES+: 559.24.

1. temperatureThe mixture is heated
2. temperatureto reflux for 30 min
3. temperatureto cool to rt
4. washwashed with aq. 1M NaOH (1×)
5. dry with materialextracts are dried over MgSO4
6. filtrationfiltered
7. customthe solvents are removed under reduced pressure
8. customPurification of the residue by FC (MeOH/CH2Cl2 1:49→1:24→3:47→2:23)