反应详情

(S)-4-Bromo-2-tert-butoxycarbonylaminobutyric acid methyl ester (0.10 g, 0.34 mmol) (prepared as in Example 120, Steps A-D) and piperidine (1 mL) were heated to 50° C. for 16 hours and then cooled to room temperature and concentrated under reduced pressure. The residue was azeotroped with toluene (3×10 mL) and then chromatographed eluting with MeOH/dichloromethane (1:9) to provide 93 mg of colorless oil (97% yield).

1. concentrationconcentrated under reduced pressure
2. customThe residue was azeotroped with toluene (3×10 mL)
3. customchromatographed
4. washeluting with MeOH/dichloromethane (1:9)