反应详情

The title compound was prepared as for example 8, steps 1 to 4. Step 1 was performed using 5-chloro-2-methoxybenzensulfonyl chloride and yielded 1-(5-chloro-2-methoxybenzenesulfonyl)-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester, which was hydrolyzed to 1-(5-chloro-2-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indole-6-carboxylic acid in step 2 and coupled to (4-amino-phenyl)-acetic acid ethyl ester and yielded (4-{[1-(5-chloro-2-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indole-6-carbonyl]-amino}-phenyl)-acetic acid ethyl ester, which was hydrolyzed to (4-{[1-(5-chloro-2-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indole-6-carbonyl]-amino}-phenyl)-acetic acid in step 4, MS (ISP): m/e=499.1 (M−H).