反应详情

Enantiomer A of butyl 1-{(trans-4-tert-butylcyclohexyl)[(4-isopropylphenyl)acetyl]amino}indane-5-carboxylate (36 mg) was saponified with aqueous LiOH and then coupled to 5-amino tetrazole following the procedure described (Step D., Example 1/2) to give 1-{(Trans-4-tert-butylcyclohexyl)[(4-isopropylphenyl)acetyl]amino}-N-1H-tetrazol-5-ylindane-5-carboxamide. HPLC/MS: m/z=543.5 (M+1), Rt=2.67 min. 1H NMR (DMSO-d6): δ 12.30 (1H, br s), 7.90 (1H, s), 7.85 (1H, d, J=8.0 Hz), 7.17 (2H, d, J=8.0 Hz), 7.10 (2H, d, J=8.0 Hz), 7.03 (1H, d, J=8.0 Hz), 4.79 (1H, m), 3.74 (2H, m), 3.06 (1H, m), 2.88 (1H, m), 2.36 (1H, m), 2.21 (1H, m), 1.74 (2H, m), 1.54 (2H, m), 1.36-0.86 (13H, m), 0.84 (9H, s).