HRID1720540

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

反应SMILES：Cl.O=C(O)[C@H](Cc1ccccc1)N1CCCCC1

HCID67771413

未命名化合物

反应SMILES：CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)COc1ccccc1

HCID70050944

未命名化合物

PRODUCTS

产物

反应SMILES：O=C([C@H](Cc1ccccc1)N1CCCCC1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)COc1ccccc1

HCID22860067

未命名化合物

收率 84.9%

PROCEDURE

实验过程

The residue obtained by treating, with 4N hydrochloric acid, (2S)-1-[N-(tert-butoxycarbonyl)-L-prolyl]-2-(1-hydroxy-2-phenoxyethyl)pyrrolidine (751 mg) prepared in Example 46-C) was subjected to condensation with (2S)-3-phenyl-2-(1-piperidinyl)propionic acid hydrochloride (500 mg) in the same manner as in Example 48-B) to give 818 mg of the title compound.

WORKUP

后处理

customThe residue obtained

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-52e902c1fd9d44bca6d0f1dca0759a43
来源数据集: uspto-grants-1996_04
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US05506256
来源说明: uspto-grants-1996_04

反应SMILES

Cl.C(O[C:7]([N:9]1[CH2:30][CH2:29][CH2:28][C@H:10]1[C:11]([N:13]1[CH2:17][CH2:16][CH2:15][C@H:14]1[CH:18]([OH:27])[CH2:19][O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:12])=[O:8])(C)(C)C.Cl.[C:32]1([CH2:38][C@H:39]([N:43]2[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]2)C(O)=O)[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[OH:27][CH:18]([C@@H:14]1[CH2:15][CH2:16][CH2:17][N:13]1[C:11](=[O:12])[C@@H:10]1[CH2:28][CH2:29][CH2:30][N:9]1[C:7](=[O:8])[C@@H:39]([N:43]1[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]1)[CH2:38][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[CH2:19][O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1