反应详情

温度

120 °C

A mixture of 3-Ethynyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenylpyridine (1.500 gm, 4.76 mmol) (The preparation of which is described in example 4) and 14 mg of AIBN in tri-n-butylstannyl hydride (Bu3SnH) (1.90 ml) was rapidly heated to 120° C. After 4 minutes of heating, the mixture was treated with additional Bu3SnH (0.4 ml) and the temperature of the reaction was raised to 130° C. Approximately 14 mg of AIBN was added to the reaction mixture 0.5, 1.5 and 2.5 hours after heating was initiated. After 4 hours, the mixture was cooled to room temperature, diluted with Et2O (40 ml) and treated with solid I2 (1.92 gm, 7.56 mmol). The dark reaction mixture was stirred for 1.5 hours, then quenched with 10% Na2SO3 in saturated NaHCO3. The layers were shaken and separated. The ethereal layer was washed with brine, dried (Na2SO4), filtered and stripped to yield a yellow oil. Flash chromatography (Merck SiO2, 1% EtOAc in hexane followed by 1.5% EtOAc in hexane afforded (E)-4-(4-Fluorophenyl)-3-(2-iodoethenyl)-2-(1-methylethyl)-6-phenylpyridine as a solid. Recrystallization of the solid from hot hexane gave 1.438 gm (E)-4-(4-Fluorophenyl)-3-(2-iodoethenyl)-2-(1-methylethyl)-6-phenylpyridine. An additional 0.19 gm of compound was obtained from the mother liquor to give a total of 1.628 gm (77%) product.

1. customThe preparation of which
2. temperatureAfter 4 minutes of heating
3. temperaturethe temperature of the reaction was raised to 130° C
4. temperatureafter heating
5. temperaturethe mixture was cooled to room temperature
6. customThe dark reaction mixture
7. customquenched with 10% Na2SO3 in saturated NaHCO3
8. stirringThe layers were shaken
9. customseparated
10. washThe ethereal layer was washed with brine
11. dry with materialdried (Na2SO4)
12. filtrationfiltered
13. customto yield a yellow oil