反应详情

3 g of 4-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylamino]piperidine are added to a solution of 1.15 g of 9-allyl-2,6-dichloropurine in 20 ml of ethanol and the mixture is stirred for 3 hours at room temperature and then for 30 minutes at 50° C. The mixture is then treated as described in Example 1. The residue obtained is recrystallised from ether. 1.8 g of white crystals melting (cap) at 146°-148° C. are obtained. By proceeding as in Example 1, starting from 1.8 g of the 2-chloropurine compound so obtained dissolved in 20 ml of butanol and heated to 150° C. in the presence of 0.6 ml of allylamine, 0.7 g of 9-allyl-2-allylamino-6-{4-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methylamino]piperidino}purine is obtained in the form of a resinous product of which the difumarate, recrystallised from ethanol, melts (cap) at 191°-194° C.

1. waitfor 30 minutes at 50° C
2. additionThe mixture is then treated
3. customThe residue obtained
4. customis recrystallised from ether
5. custom(cap) at 146°-148° C.
6. customare obtained
7. customso obtained