反应详情

N-Formyl-N-methyl-2-methylamino-α-(3-methyl-2-thienyl)benzenethanamine (4.1 g) was treated with 18 ml of 3N hydrochloric acid. After refluxing for 1.5 hours the solution was decanted over ice, basified with 12 ml of a 50% aqueous sodium hydroxide solution and extracted with dichloromethane (3×60 ml). The organic phase was dried over anhydrous sodium sulfate and concentrated to an oil. Purification of the oil was accomplished by HPLC (Water's Associates Prep LC/System 500, silica gel, elution with methanol). Concentration of the appropriate fractions afforded a residue which was dissolved in diethyl ether, filtered free of insolubles, and concentrated to afford N-methyl-2-methylamino-α-(3-methyl-2-thienyl)benzeneeethanamine as an oil. The oil was dissolved in methanol and treated with ethereal hydrogen chloride. Dilution with diethyl ether precipitated 2.4 g of the corresponding dihydrochoride salt, mp 191°-192° C.

1. temperatureAfter refluxing for 1.5 hours the solution
2. customwas decanted over ice
3. extractionextracted with dichloromethane (3×60 ml)
4. dry with materialThe organic phase was dried over anhydrous sodium sulfate
5. concentrationconcentrated to an oil
6. customPurification of the oil
7. washwas accomplished by HPLC (Water's Associates Prep LC/System 500, silica gel, elution with methanol)
8. customConcentration of the appropriate fractions afforded a residue which
9. filtrationfiltered free of insolubles
10. concentrationconcentrated
11. customto afford N-methyl-2-methylamino-α-(3-methyl-2-thienyl)benzeneeethanamine as an oil
12. customDilution with diethyl ether precipitated 2.4 g of the corresponding dihydrochoride salt, mp 191°-192° C.