反应详情

A mixture of 3.2 parts of 4-(1-ethenyl)pyridine, 2.1 parts of N-(4-piperidinyl)-2-benzoxazolamine and 80 parts of 1-butanol was stirred and refluxed for 48 hours. The reaction mixture was evaporated. The residue was purified by column chromatography over silica gel using a mixture of trichloromethane and methanol (97:3 by volume) saturated with ammonia, as eluent. The pure fractions were collected and the eluent was evaporated. The residue was crystallized from 2,2'-oxybispropane, yielding 2 parts (62%) of N-[1-[2-(4-pyridinyl)ethyl]-4-piperidinyl]-2-benzoxazolamine; mp. 146.9° C. (450).

1. temperaturerefluxed for 48 hours
2. customThe reaction mixture was evaporated
3. customThe residue was purified by column chromatography over silica gel using
4. additiona mixture of trichloromethane and methanol (97:3 by volume) saturated with ammonia
5. customThe pure fractions were collected
6. customthe eluent was evaporated
7. customThe residue was crystallized from 2,2'-oxybispropane