反应详情

The title compound was prepared using the same procedure as 6-({(S)-2-Hydroxy-3-[(R)-5-(6-methoxy-[1,5]naphthyridin-4-yl)-2-oxo-oxazolidin-3-yl]-propylamino}-methyl)-4H-pyrido[3,2-b][1,4]thiazin-3-one (GSK-207235A) except substituting C-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methylamine for C-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methylamine. 1H NMR (400 MHz, CDCl3): 0.880 (d, J=4.5 Hz, 1H); 8.25 (d, J=9.1 Hz, 1H); 7.71 (d, J=4.6, 1H); 7.56 (d, J=7.9 Hz, 1H); 7.16 (d, J=9.1, 1H); 6.88 (d, J=7.9 Hz, 1H); 6.33 (dd, J=8.9, 7.6 Hz, 1H); 4.53 (t, J=9.4, 1H); 4.04 (s, 3H); 3.87 (m, 1H); 3.75-3.82 (overlapping signals, 2H); 3.65 (dd, J=9.2, 7.2 Hz, 1H); 3.46 (s, 2H); 3.41 (dd, J=14.4, 4.1 Hz, 1H); 3.33 (dd, J=14.5, 6.7 Hz, 1H); 2.77 (dd, J=12.2, 3.4 Hz, 1H); 2.62 (dd, J=12.4, 8.3 Hz, 1H). MS (ES) m/e 497 (M+H)+.