反应详情

A suspension of 360 mg of 5-benzyloxy-3-[5-(2-piperidin-1-ylethoxy)-1H-indol-2-yl]-1H-indazole, 916 mg of ammonium formate and 120 mg of palladium in 10 ml of ethanol is placed in a reactor that is irradiated in a microwave field (Synthwave 402) at a temperature of 90° C. for 30 minutes and the reaction mixture is then filtered through a bed of celite. The filtrate is evaporated under reduced pressure and the residue is then-taken up in a mixture of ethyl acetate (150 ml) and of water (50 ml). A 30% ammonium hydroxide solution is added so as to bring the pH to 10. After separation by settling out and extraction with ethyl acetate (1×50 ml), the organic extracts are combined, dried over magnesium sulfate and then evaporated under reduced pressure. 193 mg of 3-[5-(2-piperidin-1-ylethoxy)-1H-indol-2-yl]-1H-indazol-5-ol are isolated and characterized.

1. customis placed in a reactor
2. customthat is irradiated in a microwave field (Synthwave 402) at a temperature of 90° C. for 30 minutes
3. filtrationthe reaction mixture is then filtered through a bed of celite
4. customThe filtrate is evaporated under reduced pressure
5. additionthe residue is then-taken up in a mixture of ethyl acetate (150 ml) and of water (50 ml)
6. additionA 30% ammonium hydroxide solution is added so as
7. customAfter separation
8. extractionextraction with ethyl acetate (1×50 ml)
9. dry with materialdried over magnesium sulfate
10. customevaporated under reduced pressure