反应详情

To a solution of 4.5 g of 1-[3-(p-tert.butyl-phenyl)-2-methyl-2-propenyl]-piperidine in 125 ml of alcohol are added 1.7 ml of 32% hydrochloric acid and subsequently 1.5 g of 5% palladium/carbon and the mixture is then hydrogenated. After completion of the hydrogen uptake, the catalyst is filtered, the filtrate is treated with 200 ml of 10% sodium hydroxide and extracted with ether. The combined ether extracts are washed neutral with water, dried and evaporated. By distillation there is obtained pure 1-[3-(p-tert.butyl-phenyl)-2-methyl-propyl]-piperidine of boiling point 104° C./0.032 Torr.

1. filtrationAfter completion of the hydrogen uptake, the catalyst is filtered
2. additionthe filtrate is treated with 200 ml of 10% sodium hydroxide
3. extractionextracted with ether
4. washThe combined ether extracts are washed neutral with water
5. customdried
6. customevaporated
7. distillationBy distillation there