反应详情

To 2.9 g. (36.0 mmol) of fifty percent (w/w) sodium hydroxide suspended in tetrahydrofuran (50 ml.) is added 6.0 g. (18.0 mmol) of N-amidinoisooxazolidine sulfate and the mixture stirred for one hour. Five (5.0) grams of anhydrous sodium sulfate are added and the mixture stirred for an additional hour. To this mixture are added 5.4 g. (36.0 mmol) of 2,6-dimethylphenylisocyanate and the mixture stirred for three hours. Thin layer chromotography (ethyl acetate) showed no starting isocyanate so the tetrahydrofuran is removed under vacuum. The residue is partitioned between water and chloroform. The layers are separated and the aqueous layer extracted with chloroform (1×100 ml.). The combined chloroform extracts are dried over anhydrous magnesium sulfate, filtered and concentrated to give an oil which is dissolved in methanol and acidified (pH=1) with methanolic hydrochloric acid. The methanol is removed to give an oil which is triturated with diethyl ether to give a solid which is crystallized from tetrahydrofuran/hexane to give N-[(2,6-dimethylphenylcarbamoyl)amidino] isooxazolidine hydrochloride, m.p. 147°-8° C.

1. additionis added 6.0 g
2. additionTo this mixture are added 5.4 g
3. customis removed under vacuum
4. customThe residue is partitioned between water and chloroform
5. customThe layers are separated
6. extractionthe aqueous layer extracted with chloroform (1×100 ml.)
7. dry with materialThe combined chloroform extracts are dried over anhydrous magnesium sulfate
8. filtrationfiltered
9. concentrationconcentrated
10. customto give an oil which
11. customThe methanol is removed
12. customto give an oil which
13. customis triturated with diethyl ether
14. customto give a solid which
15. customis crystallized from tetrahydrofuran/hexane