反应详情

To a suspension of (2S)-1-(2-bromoisonicotinoyloxy)-2-(2-bromoisonicotinoylamino)-3-(3,4-dimethoxyphenyl)propane (4.68 g) in methanol (100 ml) is added a 1 M lithium hydroxide (8.1 ml), and the mixture is stirred for 15 hours. The reaction mixture is concentrated under reduced pressure to remove the methanol, and the residue is extracted with methylene chloride. The extract is washed, dried, and concentrated. The residue is purified by silica gel chromatography (solvent; chloroform:acetone=5:1) to give (2S)-2-(2-bromoisonicotinoylamino)-3-(3,4-dimethoxyphenyl)-1-propanol (1.2 g).

1. concentrationThe reaction mixture is concentrated under reduced pressure
2. customto remove the methanol
3. extractionthe residue is extracted with methylene chloride
4. washThe extract is washed
5. customdried
6. concentrationconcentrated
7. customThe residue is purified by silica gel chromatography (solvent; chloroform:acetone=5:1)