反应详情

7-Fluoro-2-[N-[[2-(4-methoxybenzyl)-2-H-[1,2,4]triazol-3-yl]methyl]methylamino]-5-methyl-6-phenyl-1,3-benzoxazole-4-carbonitrile (I-164) (0.33 g, 0.68 mmol) was dissolved in trifluoroacetic acid (5 ml), and stirred at room temperature for 16 hours, then at an external temperature of about 60° C. for 6 hours. The solvent was evaporated away under reduced pressure, then ethyl acetate and aqueous sodium hydrogencarbonate solution were added, and the organic layer was separated. After drying over anhydrous sodium sulfate, the solvent was evaporated away under reduced pressure, and the resulting residue was purified by silica gel column chromatography (dichloromethane:methanol=20:1) to obtain a colorless solid (0.24 g, 97%).

1. waitat an external temperature of about 60° C. for 6 hours
2. customThe solvent was evaporated away under reduced pressure
3. additionethyl acetate and aqueous sodium hydrogencarbonate solution were added
4. customthe organic layer was separated
5. dry with materialAfter drying over anhydrous sodium sulfate
6. customthe solvent was evaporated away under reduced pressure
7. customthe resulting residue was purified by silica gel column chromatography (dichloromethane:methanol=20:1)