反应详情

温度

60 °C

A solution of tert-butyl (Z)-4-[3-(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)allyl]piperazine-1-carboxylate (0.0603 g, 0.155 mmol) in methanol (5 mL) was added with 1H-indazole-3-carboxaldehyde (0.0249 g, 0.171 mmol) and piperidine (0.0106 g, 0.124 mmol), and the mixture was stirred at 60° C. for 2 hours. The reaction mixture was concentrated, and then the residue was subjected to silica gel column chromatography (chloroform/methanol). The resulting solid was washed with a mixed solvent of 50% methylene chloride in hexane to obtain tert-butyl 4-((Z)-3-{(Z)-2-[(1H-indazol-3-yl)methylene]-6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl}allyl)piperazine-1-carboxylate (0.0303 g, 38%).

1. concentrationThe reaction mixture was concentrated
2. washThe resulting solid was washed with a mixed solvent of 50% methylene chloride in hexane