反应详情

A solution of tert-butyl 4-(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)-5,6-dihydropyridine-1(2H)-carboxylate (0.203 g, 0.587 mmol) synthesized in the same manner as that of Example B52, Step 1 in ethanol (10 mL) was added with 5% palladium/carbon (wetted with 50% water, 0.100 g), and the mixture was stirred at room temperature for 16 hours under a hydrogen atmosphere. The reaction mixture was filtered through Celite, the filtrate was concentrated, and the resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain tert-butyl 4-(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)piperidine-1-carboxylate (0.0263 g, 13%).

1. filtrationThe reaction mixture was filtered through Celite
2. concentrationthe filtrate was concentrated
3. customthe resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate)