反应详情

温度

60 °C

A solution of tert-butyl 4-[2-(6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl)ethyl]piperidine-1-carboxylate (0.120 g, 0.319 mmol) synthesized in the same manner as that of Example B57, Step 1 in methanol (5 mL) was added with 1H-pyrazolo[3,4-b]pyridine-3-carboxaldehyde (0.0469 g, 0.319 mmol) and piperidine (0.100 mL, 1.01 mmol), and the mixture was stirred at 60° C. for 2 hours. The reaction mixture was cooled to room temperature, and the precipitated solid was collected by filtration. The resulting solid was suspended in 50% ethyl acetate in hexane and thereby washed to obtain tert-butyl (Z)-4-(2-{2-[(1H-pyrazolo[3,4-b]pyridin-3-yl)methylene]-6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl}ethyl)piperidine-1-carboxylate (0.0652 g, 41%).

1. temperatureThe reaction mixture was cooled to room temperature
2. filtrationthe precipitated solid was collected by filtration
3. washwashed