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0 °C

To a solution of 5-phenyl-3-(2,2,2-trifluoroethyl)furo[2,3-d]pyrimidin-4(3H)-one (730 mg, 2.48 mmol) in DMF (10 ml) at 0° C. was added bromine (0.153 ml, 2.98 mmol). The reaction mixture was stirred at 0° C. for 1 h and then 3 h at RT. The reaction mixture was diluted with EtOAc (50 ml) and 20% w/w aq. sodium thiosulfate solution (50 ml) and the layers were separated. The organic layer was further washed with brine (2×50 ml), dried (Na2SO4) and concentrated in vacuo affording the title compound as an orange solid. LCMS RT=1.40 min, M+H+=373/375.

1. custom3 h
2. customat RT
3. customthe layers were separated
4. washThe organic layer was further washed with brine (2×50 ml)
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated in vacuo