反应详情

A solution of the compound (2.90 g, 10.46 mmol) obtained in step 4 and ethyl 4-chloroacetoacetate (1.554 mL, 11.50 mmol) in ethanol (30 mL) was stirred at 80° C. for 16 hr. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from ethyl acetate and hexane to give ethyl 2-(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acetate (3.96 g, 10.22 mmol, 98%) as a pale-yellow powder.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customthe residue was crystallized from ethyl acetate and hexane