HRID1751488

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N1CCCC1c1ncc(-c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)[nH]1

HCID57449759

未命名化合物

结构：C=C1CC(c2ncc(-c3ccc(-c4ccc5cc(-c6cnc(C7CCCN7C(=O)C(NC(=O)OC)C(C)C)[nH]6)ccc5c4)cc3)[nH]2)N(C(=O)OC(C)(C)C)C1

HCID69672771

未命名化合物

结构：C=C1CC(c2ncc(-c3ccc4cc(Br)ccc4c3)[nH]2)N(C(=O)C(NC(=O)OC)C(C)C)C1

HCID69675294

未命名化合物

PRODUCTS

生成物

结构：C=C1CC(c2ncc(-c3ccc4cc(-c5ccc(-c6cnc(C7CCCN7C(=O)OC(C)(C)C)[nH]6)cc5)ccc4c3)[nH]2)N(C(=O)C(NC(=O)OC)C(C)C)C1

HCID77335376

未命名化合物

PROCEDURE

实验过程

This compound was synthesized using the same method used to make 2-{5-[4-(6-{2-[1-(2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-naphthalen-2-yl)-phenyl]-1H-imidazol-2-yl}-4-methylene-pyrrolidine-1-carboxylic acid tert-butyl ester using (1-{2-[5-(6-Bromo-naphthalen-2-yl)-1H-imidazol-2-yl]-4-methylene-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester (0.200 g, 0.391 mmol) and 2-{5-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carboxylic acid tert-butyl ester (0.223 g, 0.508 mmol) to give 2-{5-[4-(6-{2-[1-(2-Methoxycarbonylamino-3-methyl-butyryl)-4-methylene-pyrrolidin-2-yl]-3H-imidazol-4-yl}-naphthalen-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carboxylic acid tert-butyl ester (0.040 g, 0.054 mmol). LCMS-ESI+: calc'd for C43H49N7O5: 743.38 (M+); Found: 744.73 (M+H+).

WORKUP

后处理

customThis compound was synthesized

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9bd0dd3f63a4415f8157825c3469191c
来源数据集: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09156823B2
来源说明: uspto-grants-2015_10

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:12][C:11](=C)[CH2:10][CH:9]1[C:14]1[NH:15][C:16]([C:19]2[CH:24]=[CH:23][C:22](C3C=CC4C(=CC=C(C5NC(C6CCCN6C(=O)C(NC(OC)=O)C(C)C)=NC=5)C=4)C=3)=[CH:21][CH:20]=2)=[CH:17][N:18]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:56][O:57][C:58](=[O:88])[NH:59][CH:60]([C:64]([N:66]1[CH2:70][C:69](=[CH2:71])[CH2:68][CH:67]1[C:72]1[NH:73][C:74]([C:77]2[CH:86]=[CH:85][C:84]3[C:79](=[CH:80][CH:81]=[C:82](Br)[CH:83]=3)[CH:78]=2)=[CH:75][N:76]=1)=[O:65])[CH:61]([CH3:63])[CH3:62].C(OC(N1CCCC1C1NC(C2C=CC(B3OC(C)(C)C(C)(C)O3)=CC=2)=CN=1)=O)(C)(C)C>>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:14]1[NH:15][C:16]([C:19]2[CH:24]=[CH:23][C:22]([C:82]3[CH:81]=[CH:80][C:79]4[C:84](=[CH:85][CH:86]=[C:77]([C:74]5[NH:73][C:72]([CH:67]6[CH2:68][C:69](=[CH2:71])[CH2:70][N:66]6[C:64](=[O:65])[CH:60]([NH:59][C:58]([O:57][CH3:56])=[O:88])[CH:61]([CH3:63])[CH3:62])=[N:76][CH:75]=5)[CH:78]=4)[CH:83]=3)=[CH:21][CH:20]=2)=[CH:17][N:18]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]