Hydrochloric Acid → HCID 86708807, compound

HRID 1751713Notes

Reaction equation

HRID 1751713 reaction equation
[CH3:1][O:2][C:3]([NH:5][C@@H:6]([CH:64]([CH3:66])[CH3:65])[C:7]([N:9]1[CH2:13][C@@H:12]([CH3:14])[CH2:11][C@H:10]1[C:15]1[NH:16][C:17]([C:20]2[CH:21]=[C:22]3[CH2:35][O:34][C:33]4[C:24]5=[C:25]([CH:30]=[C:31]([C:36]6[NH:40][C:39]([C@@H:41]7[CH2:45][C@H:44]([CH3:46])[CH2:43][N:42]7[C:47](=[O:63])[C@H:48]([NH:55]C(OC(C)(C)C)=O)[C:49]7[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=7)=[N:38][CH:37]=6)[CH:32]=4)[CH2:26][O:27][C:28]([CH:29]=2)=[C:23]35)=[CH:18][N:19]=1)=[O:8])=[O:4].Cl>C(O)C>[NH2:55][C@H:48]([C:49]1[CH:50]=[CH:51][CH:52]=[CH:53][CH:54]=1)[C:47]([N:42]1[CH2:43][C@@H:44]([CH3:46])[CH2:45][C@H:41]1[C:39]1[NH:40][C:36]([C:31]2[CH:32]=[C:33]3[O:34][CH2:35][C:22]4[C:23]5[C:24]3=[C:25]([CH2:26][O:27][C:28]=5[CH:29]=[C:20]([C:17]3[NH:16][C:15]([C@@H:10]5[CH2:11][C@H:12]([CH3:14])[CH2:13][N:9]5[C:7](=[O:8])[C@@H:6]([NH:5][C:3](=[O:4])[O:2][CH3:1])[CH:64]([CH3:65])[CH3:66])=[N:19][CH:18]=3)[CH:21]=4)[CH:30]=2)=[CH:37][N:38]=1)=[O:63]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69675260HCID 69675260, compound

Product 1

HCID 86708807HCID 86708807, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(S)-2-(methoxycarbonylamino)-1-((2S,4S)-2-(5-(7-(2-((2S,4S)-1-((R)-2-(t-butoxycarbonylamino)-2-phenylacetyl)-4-methylpyrrolidin-2-yl)-1H-imidazol-5-yl)-5,10-dihydrochromeno[5,4,3-cde]chromen-2-yl)-1H-imidazol-2-yl)-4-methylpyrrolidin-1-yl)-3-methylbutan-1-one, 86 mg, was treated with 0.76 mL 1.25N HCl in Ethanol at room temperature overnight, then at 50° C. for 1 hour. The mixture was concentrated under reduced pressure and further dried under high vacuum to give product (90 mg).

Workup

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customfurther dried under high vacuum

Sources & evidence

ORD record
ord-c232155c30724ddea647f3d77c5695f9
Source dataset
uspto-grants-2015_10
Patent number
US09156823B2

Reaction notes

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